Inhibition of B-cell lymphoma 6 protein (BCL-6) co-repressor binding


BCL-6 belongs to the family of BTB/POZ transcription factors and is required for rapid proliferation and differentiation of mature B-lymphocytes and antibody mutation by repressing genes involved in sensing DNA damage. The protein consists of 6 C2H2-type zinc fingers and a BTB domain that mediates homodimerization. The co-repressors peptides (SMRT, BCOR) bind to a non-conserved groove located at the homodimer interface. BCL-6 is the most commonly involved oncogene in B cell lymphomas and considered a crucial therapeutic target (Cancer Cell 2010, 17, 400-411).